CELLULAR MATRIX is a synergistic association of autologous Platelet Rich Plasma and Hyaluronic Acid. It is prepared extemporaneously in a single step in a sterile, closed system.
For the treatment of OA, Cellular Matrix combines the pain and mobility improvements of HA biopolymer with the stimulation properties of growth factors provided by PRP an autologous blood-derived product. Indeed, while the hyaluronic acid restores the viscoelastic properties of the synovial fluid in the osteoarthritic joints, A-PRP stimulates the surrounding cells, for tissue repair.
In SKIN indications, Cellular Matrix combines the hydration effect of HA biopolymer with the stimulation properties of growth factors provided by an autologous blood-derived product. Indeed, while the hyaluronic acid acts as a temporary dermal substitute, PRP stimulates the surrounding cells. The three-dimensional scaffold is promptly colonized by fibroblasts, which produce extracellular matrix components and promote the ordered reconstruction of dermal tissue.
The technology processes the patient’s blood, to use the platelets, cells and proteins for indications in various medical disciplines such as orthopedics, skincare, wound care and ophthalmology.
Platelets are the key are key actors of hard and soft tissue repair mechanisms. They provide the essential growth factors (FGF, PDGF, TGF-ß , EGF, VEGF, IGF) involved in:
Stem cell migration, differentiation and proliferation.
Stimulation of cells such as fibroblasts and endothelial cells, to induce new extracellular matrix deposition and neo-vascularization.
Plasma contains many factors essential for cell survival such as nutriments, vitamins, hormones, electrolytes and proteins. Among the plasma proteins, there are the essential molecules for the coagulation process and generation of the fibrin polymer that will serve as a scaffold for cell migration, differentiation and proliferation.
A-PRP is also used in combination with freshly extracted cells (bone marrow, adipose tissue, skin cells, etc.)
Autologous therefore non immunogenic
Release of the main growth factors involved in tissue repair and regeneration
Reduced risk of infections
Improvement of microvascularization
Stimulation of mesenchymal stem cells
Stimulation of fibroblasts growth and collagen production
Acceleration of healing process, reduction of pain and of hospitalization time